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SUMMARY:Mitochondrial vesicles in immunology and evolution - Professor Hei
 di McBride from McGill University\, Department of Neurology and Neurosurge
 ry\, Montreal\, Quebec  
DTSTART:20230126T140000Z
DTEND:20230126T150000Z
UID:TALK177797@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Mitochondria are the evolutionary daughter of alpha-proteobact
 eria and their incorporation into ancient Archae over 2B years ago marked 
 the beginning of eukaryogenesis. One of the common remaining features betw
 een mitochondria and their alpha-bacterial ancestors is the capacity to sh
 ed vesicles\, processes with a broad range of physiological functions in b
 oth bacteria and mammalian cells. We have identified critical roles for mi
 tochondrial derived vesicles (MDVs) in quality control pathways that traff
 ic complexes to the late endosome/lysosome for degradation. We have also s
 hown that MDVs are triggered during infection where they bridge the innate
  to adaptive immune signaling pathways\, processes regulated by Parkinsons
  related proteins. MDV transport to peroxisomes is also essential in perox
 isomal biogenesis pathways. I will discuss our recent findings showing a n
 ew pathway of pyroptotic cell death where MDV transport plays a central ro
 le\, and our elaboration of further functional links to multiple Parkinson
 s disease related proteins. The implications of MDVs as highly conserved p
 rocesses in evolution will also be highlighted throughout the discussion.
LOCATION:Zoom meeting
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