BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Regulation of gene expression during the awakening of the zygotic 
 genome - Dr Mounia Lagha from Institut de Génétique Moléculaire de Mont
 pellier\, France 
DTSTART:20230302T140000Z
DTEND:20230302T150000Z
UID:TALK177800@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:A fundamental question in biology is how cellular processes ar
 e so reproducible despite the inherent variations in the chemical reaction
 s governing them. During development of a multicellular organism\, precise
  control of gene expression allows the reproducible establishment of patte
 rns. Our goal is to elucidate the mechanisms responsible for precision in 
 gene expression and to link them to accuracy in cell fate decisions. My te
 am tackles this question using the early development of Drosophila as a mo
 del system\, during the maternal to zygotic transition. During this critic
 al developmental window\, patterns of gene expression are rapidly establis
 hed with remarkable reproducibility and accuracy. We use quantitative imag
 ing\, genetic manipulations\, biophysics and mathematical modeling to inte
 grate the dynamic aspects of transcription and translation. In this talk\,
  I will summarize our recent results regarding the control of transcriptio
 nal memory and transcriptional bursting by cis-regulatory elements and pio
 neer factors. I will also present our recent deployment of the Suntag meth
 od to monitor translation in living Drosophila embryos\, that lead to the 
 discovery of intragenic translational heterogeneities.
LOCATION:Part II room\, Department of Genetics and Zoom
END:VEVENT
END:VCALENDAR