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SUMMARY:The Material-Tissue Interface is Key to Bioelectronic Implant Perf
 ormance - Thomas Stieglitz
DTSTART:20220907T150000Z
DTEND:20220907T160000Z
UID:TALK178178@talks.cam.ac.uk
CONTACT:Kirsty Shepherd
DESCRIPTION:Neural interfaces form the material-tissue interface between e
 lectronic and biological circuits and systems. They must provide stable an
 d reliable functional interfaces to the target structure in chronic implan
 tations both in neuroscience experiments and especially in human clinical 
 applications. Proper selection of substrate\, insulation\, and electrode m
 aterials is of paramount importance. In addition\, aspects such as size\, 
 thickness\, and shape contribute significantly to structural biocompatibil
 ity. To establish intimate contact with neural targets\, minimize post-imp
 lantation foreign body reaction\, and maintain functionality throughout th
 e implantation period\, a comprehensive set of design parameters must be c
 onsidered. Our work focused on polyimide as the substrate and insulating m
 aterial with integrated thin film metallization as the conductor in our fl
 exible neural interface approach. Iridium oxide\, carbon\, and PEDOT serve
  as electrode coatings\, depending on the intended electrode size and appl
 ication. The scientific goal is not to compete for the smallest neural pro
 bes\, but to balance size\, stability\, and usability for each individual 
 animal model and neural target area. This trade-off increases robustness i
 n handling and improves translation of developments to daily use in neuros
 cience laboratories and implementation in first-in-human studies to invest
 igate new research hypotheses. Data from long-term aging studies and chron
 ic experiments demonstrate the applicability and reliability of thin-film 
 implants for stimulation and recording studies. Assembling systems and con
 necting microsystems with robust cables and connectors remains a major cha
 llenge in both chronic preclinical and clinical studies. Results are share
 d on reliability\, cross-talk and failure modes. Results are encouraging t
 o continue the translational research path from basic studies to the first
  human clinical trials\, which are necessary to prove that new materials\,
  technologies and devices are applicable in clinical applications and can 
 eventually be translated into an approved medical device. \n
LOCATION:Cambridge Graphene Centre Seminar Room
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