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SUMMARY:A V HILL  Lecture – The Protected Brain: Neurogenesis Under Stre
 ss - Professor Alex Gould\, Francis Crick Institute\, Imperial College\, L
 ondon
DTSTART:20221107T183000Z
DTEND:20221107T193000Z
UID:TALK178193@talks.cam.ac.uk
CONTACT:Beverley Larner
DESCRIPTION:It is estimated that 1 in 7 babies worldwide are born with low
  birth weight. In the majority of cases this is due to maternal malnutriti
 on leading to intrauterine growth restriction (IUGR). Unless severe\, IUGR
  is not life-threatening but it can affect metabolic health during adultho
 od. Interesting work on IUGR in the 1960s showed that the brain often scal
 es down much less than other developing organs. This change in body propor
 tions reflects a survival strategy called brain sparing\, whereby the proc
 ess that generates neurons (neurogenesis) is highly tolerant of malnutriti
 on. Nevertheless\, sparing is not perfect and can be associated with long-
 term neurological consequences. Brain sparing is shared across evolution\,
  from humans to Drosophila fruit flies\, and significant progress has been
  made in pinpointing its underlying protective mechanisms. Key advances ha
 ve shown how the metabolism of neural stem cells\, the cells driving neuro
 genesis\, is well adapted to the stresses of malnutrition and hypoxia. New
  instruments for imaging metabolism with single-cell resolution now promis
 e a step change in our understanding of brain sparing during IUGR and how 
 it might best be treated.
LOCATION:Bristol-Myers Squibb Lecture Theatre\, Department of Chemistry
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