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SUMMARY:Regulation of mRNA translation and decay - David Bartel\, Professo
 r of Biology\, MIT\, HHMI\, and Whitehead Institute
DTSTART:20220927T100000Z
DTEND:20220927T110000Z
UID:TALK178448@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The Bartel lab investigates the molecular pathways that regula
 te gene expression by affecting the stability or translation of mRNAs.  On
 e interest is microRNAs\, which are small regulatory RNAs that typically d
 irect the destruction of their target transcripts.  This talk will describ
 e how some unusual target transcripts direct the destruction of microRNAs\
 , and the widespread use of this phenomenon to shape metazoan microRNA lev
 els.  MicroRNAs accelerate shortening of the poly(A) tails of their mRNA t
 argets.  In most contexts\, tail shortening reduces mRNA stability\, but i
 n early development\, it reduces mRNA translation.  Indeed\, mRNA-specific
  modulation of tail lengths in the cytoplasm—both tail lengthening as we
 ll as tail shortening—plays a widespread role in regulating mRNA transla
 tion in oocytes and early embryos.  This talk will describe how these wide
 spread changes in cytoplasmic tail-lengths are specified.    
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m\, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99553714360?pwd=bVRGN3o1a0ds
 azJIMnVIemlRbjltZz09
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