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SUMMARY:Tuning of genome expression and energy metabolism during cellular 
 proliferation\, quiescence and ageing - Prof Jürg Bähler\; University Co
 llege London
DTSTART:20221206T130000Z
DTEND:20221206T140000Z
UID:TALK178514@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:After my PhD at the University of Bern (Switzerland) and short
  stays as Research Associate in Switzerland and Japan\, I worked as a Post
 doctoral Fellow with John Pringle at the University of North Carolina (Cha
 pel Hill\, USA) and with Paul Nurse at Imperial Cancer Research Fund (Lond
 on\, UK). In 2000\, I joined the Wellcome Trust Sanger Institute (Hinxton\
 , UK) as a Group Leader. I was appointed as Professor of Molecular Systems
  Biology at University College London (UCL) in 2009\, and as Director of U
 CL’s Institute of Healthy Ageing in 2019. We apply diverse genetic\, cel
 lular\, and systems-level approaches to analyse the regulation\, function 
 and evolution of genomes\, complex ageing-associated processes\, and relat
 ionships between genotype\, phenotype and environment.\n\nI will talk abou
 t some of our recent research on genome regulation and cellular ageing usi
 ng fission yeast and turquoise killifish as model systems. This includes a
  study showing that a polymorphism in the sole pyruvate kinase gene in S. 
 pombe can explain the balance between respiration and fermentation\, leadi
 ng to substantial metabolic\, regulatory and physiological adjustments. An
  ongoing project analyses cellular quiescence and embryonic dormancy in ye
 ast and killifish\, and the possible importance of unknown proteins in the
 se processes. \n\nClick here to join live - https://us06web.zoom.us/j/8593
 7878916 
LOCATION:Online via zoom &amp\; Kings Hedges Room 
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