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SUMMARY:Targeting mitochondrial nucleotide metabolism in cancer - Dr Tom M
 acVicar\; CRUK Beatson Institute 
DTSTART:20221207T130000Z
DTEND:20221207T140000Z
UID:TALK178517@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Mitochondria provide cancer cells with the remarkable metaboli
 c flexibility required to respond to signalling cues\, environmental chang
 e and therapeutic intervention. My talk will focus on our recent advances 
 in understanding how mitochondria metabolise nucleotides and regulate mito
 chondrial gene expression. We propose that mitochondrial nucleotide metabo
 lism is an untapped therapeutic target in diseases associated with aberran
 t mitochondrial gene expression including cancer. \nMy fascination with th
 e plasticity and dynamic nature of the mitochondrial network started durin
 g my PhD studies at the University of Bristol with Prof Jon Lane. I then m
 oved to Prof Thomas Langer’s lab at the Max Planck Institute for Biology
  of Ageing and University of Cologne\, Germany\, with the support of EMBO 
 and Alexander von Humboldt Postdoctoral Fellowships. We revealed that mito
 chondria can acutely rewire their proteome in response to hypoxia or nutri
 ent starvation and highlighted how mitochondrial control of nucleotide met
 abolism can regulate innate immune signalling. Upon award of a CRUK Career
  Development Fellowship\, I established my research group at the CRUK Beat
 son Institute in December 2021 with the overarching aim to uncover the met
 abolic vulnerabilities of cancer by targeting mitochondrial metabolite tra
 nsporters and mitochondrial nucleotide metabolism. We combine cell biology
  approaches\, including genetic screening and high-content imaging\, with 
 3D tumour models to dissect the mechanisms of mitochondrial reprogramming 
 during cancer progression. \n
LOCATION:Kings Hedges Room 
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