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SUMMARY:Identification of candidate neural biomarkers of OCD symptom inten
 sity and response to Deep Brain Stimulation - Dr Nicole Provenza\, Baylor 
 College of Medicine
DTSTART:20221020T113000Z
DTEND:20221020T123000Z
UID:TALK178790@talks.cam.ac.uk
CONTACT:87079
DESCRIPTION:*Abstract:* \nDespite the success of deep brain stimulation (D
 BS) for treatment of refractory obsessive-compulsive disorder (OCD)\, ther
 e are currently no robust neural signatures for obsessive-compulsive (OC) 
 symptoms or initial mood and energy improvements often associated with DBS
 . This may be due to limited opportunities available for conducting intrac
 ranial electrophysiological recordings in natural environments where fluct
 uations in symptoms take place. Recently available DBS platforms offer a w
 ay over this hurdle\, allowing for streaming of intracranial neural activi
 ty both at home and in the clinic. Here\, our goal was to identify neural 
 correlates of both OC symptom intensity and acute changes in mood and ener
 gy. We conducted longitudinal intracranial recordings in nine participants
  with refractory OCD implanted with recording-capable DBS devices targeted
  to ventral capsule/ventral striatum (VC/VS). Four of the nine participant
 s were implanted with additional sensing electrodes placed over the orbito
 frontal cortex. We captured local field potentials at home during naturali
 stic exposures to OCD triggers\, and in the clinic during variations in st
 imulation amplitude. All five participants who completed the study were cl
 inical responders to DBS therapy. Using the intracranial data collected du
 ring OCD exposures\, we computed correlations between spectral power and O
 CD symptom severity. We identified low delta-band power as a candidate neu
 ral biomarker of OC symptom intensity during symptom provocations in one p
 articipant (left VC/VS: R=-0.59\, p=0.01\; right VC/VS: R=-0.56\, p=0.04).
  Electrophysiological analysis of acute response to stimulation revealed a
  peak in VC/VS alpha band activity that was suppressed with optimal DBS. I
 n OFC\, we found a native beta band peak that shifted to alpha band with o
 ptimal DBS. We consider these VC/VS and OFC spectral changes in alpha and 
 beta bands as preliminary biomarkers of the initial changes in mood and en
 ergy commonly seen during VC/VS DBS. These signals have potential utility 
 for classification of symptom intensity and increased mood and energy in a
 daptive DBS systems for OCD. Continued opportunities for long-term\, natur
 alistic intracranial electrophysiological recordings will propel biomarker
  discovery for OCD and other psychiatric disorders.\n\n*Biography:*\nNicol
 e Provenza is a postdoctoral fellow in Dr. Sameer Sheth’s laboratory at 
 Baylor College of Medicine. Nicole completed her PhD in Biomedical Enginee
 ring in Dr. David Borton’s laboratory at Brown University in 2021\, wher
 e she was awarded the Draper Fellowship for her graduate research. Her gra
 duate work focused on developing adaptive deep brain stimulation for obses
 sive-compulsive disorder. As part of her graduate work\, Nicole developed 
 a research platform to collect intracranial local field potentials synchro
 nized with disease-relevant behavior at home to aid in identification of n
 eural biomarkers of obsessive-compulsive symptoms in natural environments.
  
LOCATION:Zoom (Please contact mho28@medschl.cam.ac.uk)
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