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SUMMARY:Huntington's disease\, the Young Adult Study (HD-YAS) - Dr Christe
 lle Langley\, University of Cambridge
DTSTART:20221103T123000Z
DTEND:20221103T133000Z
UID:TALK178793@talks.cam.ac.uk
CONTACT:87079
DESCRIPTION:*Abstract:*\nHuntington’s disease (HD) is an inherited\, neu
 rodegenerative disease\, where the striatum is particularly susceptible to
  degeneration. Studies have examined cognitive impairments in both manifes
 t and pre-manifest HD patients. We conducted a unique study where particip
 ants were very far from disease onset (mean= 23.6 years). The Huntington's
  disease Young Adult Study (HD-YAS) recruited young adults with pre-manife
 st HD (n=64) and controls (n=67) matched for age\, IQ\, and sex. All parti
 cipants underwent detailed neuropsychological assessments\, including test
 s from the Cambridge Neuropsychological Test Automated Battery and a batte
 ry assessing emotion\, motivation\, impulsivity and social cognition (EMOT
 ICOM). In a sub-set of participants we specifically examined whether cogni
 tive flexibility\, assessed by the CANTAB Intra-Extra Dimensional Set Shif
 ting Task\, was associated with frontal-striatal circuits\, previously ide
 ntified as underlying cognitive flexibility.\n\n*Biography:*\nDr Christell
 e Langley is a Cognitive Neuroscientist\, she received her PhD from the Un
 iversity of Bristol in 2018. Her PhD focused on understanding the relation
 ship between fatigue and cognition in Multiple Sclerosis\, with particular
  emphasis on the neural mechanisms. She joined the University of Cambridge
  Department of Psychiatry in Professor Barbara J. Sahakian’s lab in earl
 y 2019. In collaboration with UCL she has been examining cognitive impairm
 ent in young pre-manifest Huntington’s Disease patients and with the Uni
 versity of Copenhagen is examining the role of serotonin in cognition.
LOCATION:Zoom (Please contact mho28@medschl.cam.ac.uk)
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