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SUMMARY:Biological factors associated with the onset of psychosis - Dr Bor
 is Chaumette\, Institute of Psychiatry and Neuroscience of Paris
DTSTART:20221215T123000Z
DTEND:20221215T133000Z
UID:TALK178841@talks.cam.ac.uk
CONTACT:87079
DESCRIPTION:*Abstract:* \nOver the past 20 years\, researchers and psychia
 trists in the field of psychosis have moved from a conception of a chronic
  presentation to a more dynamic paradigm. Accordingly\, schizophrenia is 
 now conceptualized as a progressive illness that typically emerges during 
 late adolescence and transitions between several stages: early vulnerabili
 ty\, at-risk mental state (also called ultra-high risk\, abbreviated UHR)\
 , first episode of psychosis\, and chronic disease. Defining criteria to 
 identify UHR individuals has permitted research in the early stages of sch
 izophrenia. It has also been possible to conduct longitudinal studies to 
 identify biomarkers and contribute to improve understanding of the periphe
 ral biological changes accompanying conversion from prodromes to full-blow
 n psychosis. Notably\, only one quarter of UHR individuals convert to psyc
 hosis after 3 years of follow-up\, but the reasons why they do are not yet
  understood. Our team is exploring their genomic background in order to p
 redict their clinical outcome. We have also explored the longitudinal chan
 ges associated with the emergence of psychotic symptoms during the adolesc
 ence\, especially their methylome\, their transcriptome and their metabolo
 me. Those findings could be useful to identify predictive biomarkers\, to 
 understand the pathophysiology triggering psychosis and ultimately to iden
 tify new stage-specific therapeutic strategies that could prevent or delay
  the onset of this severely disabling disorder.\n\n*Biography:*\nBoris Cha
 umette\, french laureate of the Ecole de l’INSERM\, has defended his MD 
 with a specialty in psychiatry and his PhD in neurobiology in 2016. After 
 a post-doc at McGill University (Montreal-Canada)\, he has been recruited 
 in September 2022 as Associate Professor at GHU Paris Psychiatrie & Neuros
 ciences (Ste Anne Hospital) and Université Paris Cité.\nAt the hospital\
 , he is involved in the Department of Evaluation\, Prevention and Therapeu
 tic innovation and provides care for adolescents and young adults sufferin
 g from emerging psychotic disorders. He is leading the Center for Rare Psy
 chiatric Disorders which performs clinical genetic assessments and manages
  patients with rare genetic conditions and psychiatric symptoms. \nHis res
 earch activities at the Institute of Psychiatry and Neuroscience of Paris 
 (INSERM U1266) are dedicated to the genetics and epigenetics of psychiatri
 c disorders\, and aim to better understand the Gene X Environment interact
 ions during the emergence of psychosis in adolescence.\nBoris Chaumette is
  the vice-chair of the European COST Action to Enhance Psychiatric Genetic
  Counselling\, Testing\, and Training in Europe (EnGagE network\, funded b
 y the EU Horizon 2020 program). He co-manages the International Research N
 etwork Dev-O-Psy exploring the biological bases of early phases of psychos
 is. For more information on Dr Chaumette\, please visit: https://www.insti
 tutimagine.org/fr/users/borischaumetteinsermfr\n
LOCATION:Herchel Smith Building Seminar Room and on Zoom (contact mho28@me
 dschl.cam.ac.uk) 
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