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SUMMARY:Designing multiphase biomolecular condensates - Pin Yu Chew\, Univ
 ersity of Cambridge
DTSTART:20221116T143000Z
DTEND:20221116T150000Z
UID:TALK178859@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:Biomolecular condensates are highly multi-component systems in
  which complex phase behaviour can ensue\, including the formation of arch
 itectures comprising multiple immiscible condensed phases. Relying solely 
 on physical intuition to manipulate them is difficult because of the compl
 exity of their composition. We address this challenge by developing a comp
 utational approach which couples a genetic algorithm to a residue-resoluti
 on coarse-grained protein model to design pairs of protein sequences that 
 result in well-separated multilayered condensates. We find that the balanc
 e of homo- and heterotypic interaction energies between the two components
  is important for controlling multiphase organisation\, and our approach f
 or designing multilayered condensates achieves this balance of interaction
  energies by optimising the composition and patterning of the protein sequ
 ences.
LOCATION:Wolfson Lecture Theatre\, Dept of Chemistry and Zoom
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