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SUMMARY:Using natural epitopes to uncover disease mechanisms in autoimmune
  diabetes - Prof. Mark Peakman\, King's College London School of Medicine\
 , Guy's Hospital London
DTSTART:20090429T113000Z
DTEND:20090429T123000Z
UID:TALK17893@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:Professor Mark Peakman\nTrained in medicine at University Coll
 ege Hospital and pursued postgraduate training in clinical immunology. PhD
  in immunology of type 1 diabetes followed by senior clinical research fel
 lowship at University of Pittsburgh on identification of naturally process
 ed and presented T cell epitopes.\nEstablished research group at King’s 
 College London in the Department of Immunobiology.\n\nResearch Interests:\
 nThe main focus of the research group is the immunopathogenesis of the aut
 oimmune disease\, type 1 diabetes (T1D). T1D is the third commonest autoim
 mune disease in the UK after thyroid autoimmunity and rheumatoid arthritis
 . Because it is a chronic condition typically diagnosed in early childhood
  its impact on morbidity and mortality through cardiovascular\, renal and 
 visual complications is considerable\; as a result it costs the NHS around
  £1-2 billion annually to manage. Our research focuses on T lymphocytes. 
 Through defining critical disease epitopes we have been able to examine CD
 4 and CD8 responses to beta cell autoantigens and begin to unravel disease
  mechanisms. More recently we have used this knowledge to conduct the firs
 t clinical trial in T1D of peptide immunotherapy.\n
LOCATION:Lecture Theater\, Department of Pathology\, Tennis Court Road
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