BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Families of IgSF receptors - Prof. John Trowsdale\, Department of 
 Pathology and CIMR\, University of Cambridge
DTSTART:20090422T113000Z
DTEND:20090422T123000Z
UID:TALK17894@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:John Trowsdale Research\n\nThe human major histocompatibility 
 complex (MHC) encodes the most polymorphic proteins in the human genome an
 d is associated with more diseases than any other region. Unravelling this
  complex of human loci\, from sequence to function\, will help to understa
 nd autoimmune diseases such as diabetes\, multiple sclerosis and arthritis
 . The class I and class II molecules encoded by the MHC play a pivotal rol
 e in alerting the rest of the immune system to disease by interacting with
  receptors on T cells. A major part of our work concerns these molecules. 
 Other genes embedded in the MHC provide additional clues to mechanisms of 
 immune recognition and we are studying the functions of some of them\, inc
 luding MOG and BTN.\n\nFurther information on the state of health of a cel
 l is provided by interaction of MHC class I molecules with other receptors
 \, on natural killer (NK) cells. Like some MHC genes\, the NK receptors ar
 e part of extensive gene families. They are involved in activating\, or in
 hibiting NK cells and some T cells. We are studying the organisation of th
 e NK-receptor gene families\, their polymorphism and association with dise
 ase\, particularly in relation to interaction of the receptors with differ
 ent MHC class I molecules.\n
LOCATION:Lecture Theater\, Department of Pathology\, Tennis Court Road
END:VEVENT
END:VCALENDAR