BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Alternatively activated macrophages in helminth infection: a parad
 igm for Th2 immunity - Professor Judith Allen\, Institute of Infection and
  Immunology Research\, University of Edinburgh
DTSTART:20090513T113000Z
DTEND:20090513T123000Z
UID:TALK17896@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:The Allen laboratory has a particular interest in Th2-type imm
 unity and focuses primarily on infection with helminths.  The role of the 
 Th2 immune response in clearing helminths from the gastro-intestinal tract
  is clear\, but its role in the tissues is less certain.  Our analysis of 
 macrophages activated by Th2 cytokines during tissue nematode infection re
 vealed that the most abundant proteins produced and secreted by these cell
 s are associated with injury and repair.  This suggests that a primary fun
 ction of the Th2 response may be to repair damage mediated by large extrac
 ellular parasites. We hypothesize that Th2 cells evolved as the arm of the
  adaptive immune system that controls innate wound healing responses.  The
 se studies have implications for diseases beyond helminth infection\, wher
 e the wound healing response is dysregulated\, such as asthma\, fibrosis a
 nd cancer.  \n\nWebsite: www.nematodes.org/allenlab/\nFunding:  MRC\, EU\,
  Asthma UK\n\nSome recent publications:\n\n P Loke\,  I  Gallagher\, MG Na
 ir\, XX Zang\, F Brombacher\, M Mohrs\, JP Allison & JE Allen. 2007.  Alte
 rnative Activation is an Innate Response to Injury that Requires CD4+ T-ce
 lls to be Sustained During Chronic Infection. Journal of Immunology. 179:3
 926-36.\n\nA Diaz & JEAllen. 2007. Mapping immune response profiles: the e
 merging scenario from helminth immunology.  European Journal of Immunology
 . 37: 3319-3326\n\nKJ Mylonas\, MG Nair\, L Prieto-Lafuente\, D Paape\, JE
  Allen. 2009 Alternatively activated macrophages elicited by helminth infe
 ction can be reprogrammed to enable microbial killing. Journal of Immunolo
 gy. 182:3084-94.\n\nT Sutherland\, RM  Maizels & JE Allen. 2009.  Chitinas
 es in allergic Inflammation. Clincal & Experimental Allergy.  Epub ahead o
 f print.\n
LOCATION:Lecture Theater\, Department of Pathology\, Tennis Court Road
END:VEVENT
END:VCALENDAR