BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Regulatory T cells inhibit antigen-dependent T cell function but n
 ot bystander T cell activity: implications for pathogenesis of RA - Profes
 sor Fionula Brennan\, Kennedy Institute of Rheumatology\, Imperial College
  London
DTSTART:20090527T113000Z
DTEND:20090527T123000Z
UID:TALK17898@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:Professor Fionula Brennan\n\nMy research interests over the la
 st 20 years or so have focussed on cytokine regulation in chronic inflamma
 tory disease.  My research studies indicated the importance of TNF as a po
 tential therapeutic target in rheumatoid arthritis\, which led to the firs
 t trials of anti-TNF antibodies in RA in man.  \n\nMore recently I have st
 udied how T cells in the synovial joint drive chronic inflammation.  These
  studies indicate that these T cells resemble 'by-stander' activated T cel
 ls (not antigen-driven) and studies on a surrogate model for these RA syno
 vial T cells have indicated the cell surface molecules important for conta
 ct-dependent activation of macrophages.  \n\nIn the seminar today I will d
 iscuss very recent data on regulatory T cell function in this surrogate T 
 cell model\, and how this contributes to regulation of inflammation in chr
 onic inflammatory diseases.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
END:VEVENT
END:VCALENDAR