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SUMMARY:Evolution of nutrient co-limitation in microbial communities - Mic
 hael Manhart (ETH Zurich)
DTSTART:20221012T091000Z
DTEND:20221012T093000Z
UID:TALK179354@talks.cam.ac.uk
DESCRIPTION:Microbial growth relies on the presence of several nutrients\,
  including elemental nutrients such as carbon and nitrogen\, as well as co
 mplex nutrients like vitamins and amino acids. &nbsp\;Evidence from biogeo
 chemistry\, especially in aquatic environments\, suggests that multiple nu
 trients may be simultaneously rare in nature and therefore limit growth. &
 nbsp\;However\, we poorly understand how this co-limitation affects microb
 ial growth\, physiology\, and evolution. &nbsp\;This is especially importa
 nt in the context of multi-species communities\, where pervasive cross-fee
 ding of many nutrients leads to the coevolution of nutrient limitation bet
 ween species. &nbsp\;We introduce a theoretical framework for understandin
 g and quantifying nutrient limitation\, which we apply to an evolutionary 
 model to show how limitation for multiple nutrients evolves. &nbsp\;We fin
 d that evolution can spontaneously drive nutrient uptake to match environm
 ental availability\, leading to co-limitation of multiple nutrients. &nbsp
 \;We show how this result depends on the interaction between nutrients and
  supply of adaptive mutations. &nbsp\;In particular\, we demonstrate how n
 utrient limitation coevolves across species in cross-feeding communities. 
 &nbsp\;This prediction is consistent with observed correspondences between
  the elemental composition of microbes and their environments. &nbsp\;It s
 uggests that co-limitation may be a generic property of microbial communit
 ies due to evolutionary forces.
LOCATION:Seminar Room 1\, Newton Institute
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