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SUMMARY:Taming your inner parasite: novel tools to study cryptosporidiosis
  - Dr Adam Sateriale (Francis Crick Institute)
DTSTART:20221109T160000Z
DTEND:20221109T170000Z
UID:TALK180506@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:The Cryptosporidium parasite is a leading cause of diarrheal d
 isease in children around the world. While acute infections can be fatal\,
  even mild infections are strongly correlated to malnutrition and subseque
 nt growth stunting. Despite this significant impact on global public healt
 h\, there are no fully effective treatments and our fundamental understand
 ing of infection biology is sorely lacking. To drive the research field fo
 rward\, we isolated a strain of Cryptosporidium tyzzeri\, a natural mouse 
 pathogen that is a close relative of the Cryptosporidium hominis species t
 hat infects humans. Leveraging CRISPR-directed homology repair\, we develo
 ped a fully tractable mouse model that allows for genetic manipulation of 
 both host and parasite. Using this model\, we’ve identified NLRP6 driven
  inflammation as an important first line of defence against infection. We 
 are now expanding this model into genome wide screens to identify and defi
 ne other important molecular mechanisms of parasite virulence and host res
 istance to infection. \n\nWe encourage in person attendance but the talk w
 ill also be streamed via "zoom":https://zoom.us/j/92211019683?pwd=ZUY4eHRa
 MkxKT3I0b215SlVtMlkwQT09
LOCATION:Seminar Room\, Tennis Court Road\, Dept of Pathology.
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