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SUMMARY:Principles of Protein Structural Ensembles Determination - Michele
  Vendruscolo\, Co-Director\, Centre for Misfolding Diseases\, Yusuf Hamied
  Department of Chemistry
DTSTART:20221102T140000Z
DTEND:20221102T150000Z
UID:TALK182309@talks.cam.ac.uk
CONTACT:Samantha Noel
DESCRIPTION:Achieving a comprehensive understanding of the behaviour of pr
 oteins is greatly facilitated by the knowledge of their structures\, therm
 odynamics and dynamics. This information can be provided in an effective m
 anner in terms of structural ensembles. A structural ensemble can be obtai
 ned by determining the structures\, populations and interconversion rates 
 for all the main states that a protein can occupy. I will describe how the
  well-established principles of protein structure determination should be 
 extended to the case of protein structural ensembles determination. These 
 principles concern primarily how to deal with conformationally heterogeneo
 us states\, and with experimental measurements that are averaged over such
  states and affected by a variety of errors. I will address some conceptua
 l problems in the determination of structural ensembles and define future 
 goals towards the establishment of objective criteria for the comparison\,
  validation\, visualization\, and dissemination of such ensembles. 
LOCATION:CMS\, Meeting Room 15
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