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SUMMARY:Can small RNAs help address the big issues in helminth parasite co
 ntrol? - Dr Paul McVeigh (Queen's University\, Belfast)
DTSTART:20230208T160000Z
DTEND:20230208T170000Z
UID:TALK182780@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:Understanding how parasites interact with and survive within t
 heir hosts is a key challenge for parasitologists. Much effort is directed
  towards decoding the parasite “secretome” – the repertoire of molec
 ules secreted by parasites to aid their survival. Helminth parasite secret
 omes are now known to contain several RNA species in addition to classical
 ly recognised proteins\, lipids and sugars. These molecules are essential 
 contributors to parasite-host communication\, but also represent potential
  biomarkers which could contribute to improved detection and diagnosis of 
 parasitic infections. Our team focuses on the secreted micro (mi)RNA compo
 nent of helminth secretomes\, through RNA sequencing of plasma from experi
 mentally- and naturally-infected animals. I will present data from two rep
 resentative species: Fasciola hepatica\, a trematode liver fluke\, and Str
 ongyloides ratti\, a gastrointestinal nematode. I will present our latest 
 insights from longitudinal plasma miRNA sequencing datasets from both spec
 ies\, from the dual perspectives of how extracellular miRNAs could allow p
 arasites to control host gene expression\, and how we might apply these da
 ta to improved parasite diagnostics and control.\n\nWe encourage in person
  attendance but the talk will also be streamed via "zoom":https://zoom.us/
 j/97778512051?pwd=L25RZWpQRjlObHNUYVQzUG5nelpoZz09\n
LOCATION:Seminar Room\, Tennis Court Road\, Dept of Pathology.
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