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SUMMARY:The role of small non-coding RNAs in Strongyloides parasitism - Dr
  Vicky Hunt (University of Bath)
DTSTART:20230510T150000Z
DTEND:20230510T160000Z
UID:TALK182789@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:Small non-coding RNAs are involved in posttranscriptional regu
 lation of genes and transposable elements. They have two possible roles in
  parasitism: (i) regulation of endogenous transcripts with a direct role i
 n parasitism or other aspects of the parasitic life cycle\, and (ii) they 
 are secreted into the host where they target and regulate host transcripts
 \, for the benefit of the parasite. We have investigated both roles of sma
 ll non-coding RNAs in the gastrointestinal parasites Strongyloides ratti a
 nd S. venezuelensis. Families of putative small-interfering RNA are predic
 ted to have roles in reproductive biology and regulating transposable elem
 ent activity. We have also identified Strongyloides-derived small RNAs sec
 reted in exosome-like vesicles into the host and taken up by intestinal ep
 ithelial cells. These secreted small non-coding RNAs are predicted to targ
 et host genes and manipulate the host peristalsis response. Secreted small
  non-coding RNAs are detectable in host faeces and have potential as a dis
 ease biomarker.\n\n\nThis is a hybrid talk - "Zoom link":https://zoom.us/j
 /98476028413?pwd=bGhORDM1SDlSVEpVUnlyRlczcEQ3UT09
LOCATION:Seminar Room\, Tennis Court Road\, Dept of Pathology.
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