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SUMMARY:Anterior Insula and Prospect Theory - Veit Stuphorn\,  Department 
 of Neuroscience\, Krieger Mind/Brain Institute\, Johns Hopkins University\
 , Baltimore\, MD\, U.S.A.
DTSTART:20221010T151500Z
DTEND:20221010T170000Z
UID:TALK183086@talks.cam.ac.uk
CONTACT:Prof. Wolfram Schultz
DESCRIPTION:In humans\, risk attitude is highly context-dependent\, varyin
 g with wealth levels or for different potential outcomes\, such as gains o
 r losses. These behavioral effects have been modelled using prospect theor
 y\, with the key assumption that humans represent the value of each availa
 ble option asymmetrically as a gain or loss relative to a reference point.
  It remains unknown how these computations are implemented at the neuronal
  level. Here we show that macaques\, like humans\, change their risk attit
 ude across wealth levels and gain/loss contexts using a token gambling tas
 k. Neurons in the anterior insular cortex (AIC) encode the 'reference poin
 t' (i.e.\, the current wealth level of the monkey) and reflect 'loss avers
 ion' (i.e.\, option value signals are more sensitive to change in the loss
  than in the gain context) as postulated by prospect theory. In addition\,
  changes in the activity of a subgroup of AIC neurons correlate with the i
 nter-trial fluctuations in choice and risk attitude. Taken together\, we s
 how that the primate AIC in risky decision-making may be involved in monit
 oring contextual information used to guide the animal's willingness to acc
 ept risk.
LOCATION:Zoom only
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