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SUMMARY:Branching morphogenesis of the lung: tales of the sculptor and the
  sculpture    - Katharine Goodwin (Princeton\, MRC LMB) 
DTSTART:20221121T143000Z
DTEND:20221121T153000Z
UID:TALK183125@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:Branching morphogenesis transforms simple tubes of cells into 
 vast\, tree-like networks essential for organ function. In the embryonic m
 ouse lung\, smooth muscle differentiation around the airway epithelium phy
 sically shapes emerging branches. Here\, we delved into the behavior of th
 e sculptor itself\, airway smooth muscle\, and examined how it influences 
 cell fate patterns within the underlying sculpture\, the airway epithelial
  tree. Using genetic perturbations and single-cell bioinformatics\, we dem
 onstrate phenotypic plasticity in airway smooth muscle that ensures robust
  branching morphogenesis. Then\, using genetic and mechanical perturbation
 s of epithelial fate and form\, we show that patterns of epithelial cell f
 ate depend on the physical signals imposed by branching morphogenesis and 
 airway smooth muscle wrapping. 
LOCATION:Online
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