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SUMMARY:Dynamics and mechanics of cell shape changes during cellular state
  changes  - Ewa Paluch\, Department of Physiology\, Development and Neuros
 cience\, University of Cambridge. 
DTSTART:20221128T143000Z
DTEND:20221128T153000Z
UID:TALK183128@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:A precise control of cell morphology is key for cell physiolog
 y\, and cell shape deregulation is at the heart of many pathological disor
 ders\, including cancer. Furthermore\, transitions between cellular states
  are often associated with changes in cell shape\, and strong evidence poi
 nts to the existence of feedbacks between mechanics\, morphology and cell 
 state. \nCell morphology is intrinsically controlled by mechanical forces 
 acting on the cell surface. In animal cells\, cell surface mechanics are p
 rimarily determined by the cellular cortex\, a thin network of actin filam
 ents and myosin motors underlying the plasma membrane. We investigate how 
 the mechanical properties of the cell surface arise from the microscopic o
 rganisation of the cortex\, and how changes in these properties drive cell
  deformation. We also investigate cell shape dynamics when cells transitio
 n between different cellular states\, such as during differentiation\, cel
 l division\, or EMT. Using a combination of cell biology experiments\, qua
 ntitative imaging and physical modelling\, we aim to understand the contro
 l of cell shape across scales. 
LOCATION:Online
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