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SUMMARY:How can we treat visceral pain? - Dr David Bulmer\, Department of 
 Pharmacology
DTSTART:20221129T160000Z
DTEND:20221129T170000Z
UID:TALK183473@talks.cam.ac.uk
CONTACT:Dr Dervila Glynn
DESCRIPTION:*Theme: Beyond the Neuron: Glia\, vascular and immune cells*\n
 \nHow can we treat visceral pain?\n\n*Abstract:* Chronic pain is a leading
  cause of morbidity\, common to patients with gastrointestinal diseases su
 ch as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).
  Most pain killers are largely ineffective against this type of pain or re
 stricted for use in these patients due to gut related complications and ri
 sk of addition. A significant unmet clinical need therefore exists to deve
 lop novel non-opioid based visceral analgesics.\n\nTo address the problem 
 work in my lab has used a combination of transcriptomic and functional app
 roaches using human tissue from well stratified patient populations to stu
 dy the causes of visceral pain in IBS and IBD.\n\nIn this talk I will desc
 ribe some of our recent findings which have led to the identification of d
 iscrete mediator – nociceptor signalling pathways in IBS patient subtype
 s and highlight the potential utility of GPCR and ion channels targets for
  the treatment of visceral pain.\n\n*Biography:* Dr David Bulmer completed
  his PhD at UCL before joining GlaxoSmithKline as an electrophysiologist a
 nd later team leader within the Neurology & GI Centre of Excellence in Dru
 g Discovery. In 2009 David took up a position at Queen Mary University of 
 London on an MRC Skills Gap Fellowship\, where he set up a translational n
 euroscience lab dedicated to the use of human tissue to study visceral noc
 iception in gastrointestinal disease. David has been invited to speak on h
 is work at international meetings such as the World Congress on Pain\, Soc
 iety for Neuroscience\, and the Digestive Disease Week. In 2017 he moved t
 o the Department of Pharmacology at the University of Cambridge where he i
 s an Associate Professor and continues to research into the causes of pain
  in IBS and IBD.\n\nRegister in advance for this meeting:\nhttps://us02web
 .zoom.us/meeting/register/tZUkd-qsqTguEt1hQxEXCxWOiOCofjqZhfpf \n\nAfter r
 egistering\, you will receive a confirmation email containing information 
 about joining the meeting.
LOCATION:Register on Zoom - link in abstract
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