BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Stem Cells and Repairing the Brain - Professor Robin Franklin
DTSTART:20090511T184500Z
DTEND:20090511T200000Z
UID:TALK18354@talks.cam.ac.uk
CONTACT:David Gordon
DESCRIPTION:Remyelination\, the process by which new myelin sheaths are re
 stored to demyelinated axons\, represents one of the most compelling examp
 les of adult stem cells contributing to regeneration of the injured CNS. T
 his process can occur with remarkable efficiency in both clinical disease\
 , such as multiple sclerosis\, and in experimental models\, revealing an i
 mpressive ability of the adult CNS to repair itself. However\, the inconsi
 stency of remyelination in multiple sclerosis\, and the loss of axonal int
 egrity that results from its failure\, makes enhancement of remyelination 
 an important therapeutic objective. Identifying potential targets will dep
 end on a detailed understanding of the cellular and molecular mechanisms o
 f remyelination. This talk will review 1) the nature of the cell or cells 
 that respond to demyelination and generate new oligodendrocytes\, identify
 ing current areas of uncertainty and addressing the role of adult CNS stem
  and progenitor cells\, 2) intrinsic factors regulating precursor differen
 tiation and 3) how an environment favourable to remyelination is generated
 \, and will introduce the concept of a matrix of signalling events critica
 l for the successful completion of remyelination.\n\nBio: Robin Franklin o
 btained his undergraduate degrees in Physiology and Veterinary Medicine an
 d his PhD in Neuroscience. He has spent his entire career at the Universit
 y of Cambridge\, where he is currently Professor of Neuroscience. He has w
 orked predominantly on the biology of myelin repair (remyelination) and in
 vestigating strategies by which this important regenerative process may be
  enhanced therapeutically\, and has published over 185 papers and reviews 
 on this topic.\n\n
LOCATION:Nihon Room\, Pembroke College
END:VEVENT
END:VCALENDAR