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SUMMARY:Simulating the Tumor Microenvironment for Immune Cell Interactions
  via Deployable Extrusion  - Corrado Mazzaglia\, CUED
DTSTART:20221028T133000Z
DTEND:20221028T140000Z
UID:TALK183701@talks.cam.ac.uk
CONTACT:Hilde Hambro
DESCRIPTION:Three-dimensional (3D) bioprinting has emerged as a promising 
 tool for constructing tumor microenvironments (TME) for cancer modelling i
 n vitro. Realizing the translational impacts of 3D bioprinting for cancer 
 research necessitates innovation in bioprinting workflows which integrate 
 affordability\, user-friendliness\, and biological relevance. Herein\, we 
 demonstrate ‘bioArm’\, a simple\, yet highly effective extrusion biopr
 inting platform\, which can be folded into a carry-on pack\, and rapidly d
 eployed between bio-facilities. BioArm enabled TME reconstruction in the f
 orm of 3D core-shell tumoroids with cancer-associated fibroblasts (CAFs). 
 Tumoroids showed the presence of a heterogenous population of CAFs with de
  novo synthesized extracellular matrices\, demonstrating more in vivo-like
  characteristics compared to conventional 2D co-culture models. Embedding 
 the 3D printed tumoroids in an immune cell laden collagen matrix permitted
  tracking of the interaction between immune cells and tumoroids\, and subs
 equent immunotherapy treatments. Our deployable extrusion bioprinting work
 flow could significantly widen the accessibility of 3D bioprinting for gai
 ning mechanistic understanding in TME\, and for developing strategies in c
 ancer drug testing.
LOCATION:Oatley Seminar Room\, Department of Engineering
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