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SUMMARY:Microglial immunophenotype in the human brain - Prof. Delphine Boc
 he. University of Southampton\, UK
DTSTART:20230306T160000Z
DTEND:20230306T170000Z
UID:TALK183728@talks.cam.ac.uk
CONTACT:Timothy Birkle
DESCRIPTION:Genome wide association studies have implicated several inflam
 mation-related genes as risk factors for Alzheimer’s disease\, particula
 rly in relation to innate immunity\, suggesting a component of microglial 
 activity is likely to be causal in the pathogenic pathway.  Therefore\, we
  have developed a number of microglial markers to immunophenotype microgli
 a in the human brain.  I will present our findings on microglial immunophe
 notype obtained on human post-mortem cohorts of Alzheimer’s disease and 
 dementia with Lewy bodies as well as on our unique cohort of brains from A
 lzheimer’s patients enrolled in the first clinical trial of Aβ42 immuno
 therapy (AN1792\, Elan Pharmaceuticals).  These studies highlight the comp
 lexity and diversity of microglial responses in dementia and their involve
 ment in therapeutic studies.
LOCATION:https://zoom.us/j/94128601767?pwd=UklLN2h5ZGNVL3BMYVNqdXh3djRXZz0
 9
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