BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Microglia and astrocyte involvement in synapse loss in Alzheimer
 ’s disease - Prof. Tara Spires-Jones. University of Edinburgh\, UK
DTSTART:20230502T150000Z
DTEND:20230502T160000Z
UID:TALK183734@talks.cam.ac.uk
CONTACT:Timothy Birkle
DESCRIPTION:Synapse loss is the strongest pathological correlate of cognit
 ive decline in Alzheimer’s disease (AD) and genetic data strongly implic
 ate both amyloid beta and changes in microglia in disease pathogenesis. In
  this talk\, Prof Spires-Jones will talk about her work showing that (1) A
 myloid beta (Ab) accumulates in synapses and contributes to synapse loss\,
  (2) APOE4 and CLU risk genes associated with synapse loss\, (3) Astrocyte
 s and microglia ingest synapses in human AD brain\, and (4) Blocking MFGE8
  binding integrin receptors reduces human synapse phagocytosis by microgli
 a and astrocytes.\n
LOCATION:https://zoom.us/j/94128601767?pwd=UklLN2h5ZGNVL3BMYVNqdXh3djRXZz0
 9
END:VEVENT
END:VCALENDAR