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SUMMARY:The ins and outs of cellular quiescence - Alexis Barr\, MRC London
  Institute of Medical Sciences
DTSTART:20221101T123000Z
DTEND:20221101T133000Z
UID:TALK183905@talks.cam.ac.uk
CONTACT:Michael Boemo
DESCRIPTION:The majority of cells in the adult body are not proliferating 
 and a fraction of these cells are quiescent. Quiescence is a state of reve
 rsible cell cycle arrest\, from which cells can be stimulated to re-enter 
 the cell cycle. During tissue maintenance and repair\, the transition from
  quiescence to proliferation and proliferation to quiescence must be caref
 ully regulated to maintain tissue size and function. Aberrant regulation o
 f these cell cycle control mechanisms can drive the continuous proliferati
 on of cells\, promoting tumorigenesis. Our aim is to understand how cells 
 enter\, maintain and exit quiescent states. We investigate how these syste
 ms are controlled in non-transformed human cells and how quiescence in can
 cer cells may provide tumour cells with a survival advantage. To answer ou
 r questions\, we use a combination of quantitative single-cell timelapse i
 maging\, gene-editing\, modelling\, bioinformatics\, screening and proteom
 ics. This combined approach allows us to gain a systems-level understandin
 g of transitions into and out of quiescence\, while challenging long-held 
 assumptions about cell cycle control. I will present recent data from the 
 lab showing how cell size can influence the proliferative potential of qui
 escent cells and how modelling is providing us with a revised and more acc
 urate view of cell cycle entry.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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