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SUMMARY:Bioelectronic tools to study the gut-brain axis - Prof Roisin Owen
 s
DTSTART:20221107T180000Z
DTEND:20221107T193000Z
UID:TALK184880@talks.cam.ac.uk
CONTACT:Daniel Lim
DESCRIPTION:The human gut microbiome has emerged as a key player in the bi
 directional communication of the gut-brain axis\, affecting various aspect
 s of homeostasis and pathophysiology. Until recently\, the majority of stu
 dies that seek to explore the mechanisms underlying the microbiome-gut-bra
 in axis relied almost exclusively on animal models\, and particularly gnot
 obiotic mice. Despite the great progress made with these models\, various 
 limitations\, including ethical considerations and interspecies difference
 s that limit the translatability of data to human systems\, pushed researc
 hers to seek for alternatives. Physiologically relevant in vitro human mod
 els\, as well as advanced tools to study in vivo animal models\, are urgen
 tly required. In this talk I’ll discuss a new generation of electronic t
 ools\, based on organic electronic materials\, for understanding the gut-b
 rain-microbiome axis.  First\, I’ll discuss our progress towards generat
 ing a complete platform of the human microbiota-gut-brain axis with integr
 ated monitoring and sensing capabilities. Bringing together principles of 
 materials science\, tissue engineering\, 3D cell biology and bioelectronic
 s\, we are building advanced models of the GI and the BBB/NVU\, with integ
 rated real-time and label-free electronic monitoring\, aiming to elucidate
  the role of microbiota in the gut-brain axis communication. Second\, I’
 ll discuss conformable electronic devices we’ve developed for both ex-si
 tu measurements of GI tissue from rats\, as well as in vivo experiments in
  live rats. These devices allow highly sensitive monitoring of impedance o
 f the tissue (as an indicator of gut health) as well as the enteric nervou
 s system.
LOCATION:Wolfson Lecture Theatre\,  Department of Chemistry\, Lensfield Ro
 ad
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