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SUMMARY:Nanoscale Engineering of Plasmonic Materials for Biosensing and Bi
 oimaging - Prof Fang Xie
DTSTART:20221114T180000Z
DTEND:20221114T193000Z
UID:TALK184883@talks.cam.ac.uk
CONTACT:Daniel Lim
DESCRIPTION:"Early diagnosis plays an increasingly significant role in cur
 rent clinical drive. Detection\, identification\, and quantification of lo
 w abundance biomarker proteins form a promising basis for early clinical d
 iagnosis and offer a range of important medical benefits. Amplification of
  light from NIR fluorophores by coupling to metal nanostructures\, i.e. Me
 tal Induced Fluorescence Enhancement (MIFE)\, represents a promising strat
 egy for dramatically improving the detection and quantification of low abu
 ndance biomarker proteins\, and potentially increase already sensitive flu
 orescence-based detection by up to three orders of magnitude. The amplific
 ation of the fluorescence system is based on interaction of the excited fl
 uorophores with the surface plasmon resonance in metallic nanostructures. 
 The enhanced fluorescence intensity due to the existence of metal nanostru
 ctures makes it possible to detect much lower levers of biomarkers tagged 
 with fluorescence molecules either in sensing format or for tissue imaging
 . The first part of my talk will focus on some recent developments of plas
 monic metal nanostructures by both top-down and bottom up methods. I will 
 then discuss the prepared plasmonic nanostructures in the applications of 
 biosensing and bioimaging\, with the emphasis on plasmonic enhancement tow
 ards NIR I and NIR II regions."
LOCATION:Wolfson Lecture Theatre\,  Department of Chemistry\, Lensfield Ro
 ad
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