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SUMMARY:Translating between mouse and human microbiota research - Dr Virgi
 nia Pedicord - Cambridge Institute of Therapeutic Immunology &amp\; Infect
 ious Disease
DTSTART:20221129T203000Z
DTEND:20221129T220000Z
UID:TALK184910@talks.cam.ac.uk
CONTACT:Toby Nuttall
DESCRIPTION:The gut microbiota affects numerous aspects of human health\, 
 including host metabolism\, immunity and brain function. Sequencing method
 s have revolutionized our understanding of the taxonomic identities of mem
 bers of the human gut microbiota and their associations with various disea
 ses. However\, important barriers have remained in the microbiota field\, 
 namely a lack of resources for functional and mechanistic studies and conc
 erns about the application and relevance to human disease of microbiota re
 search performed in animal models. To help overcome these barriers\, we ha
 ve developed biological and bioinformatic tools that now enable us to map 
 and test functional capabilities of the gut microbiota from mice and human
 s to establish how multiple microbial species with shared functions can ac
 hieve similar effects on host immune and neuronal phenotypes. Using these 
 resources we are now elaborating the mechanisms by which metabolites from 
 commensal gut microbes modulate infection susceptibility\, neuronal develo
 pment and responses to tumour immunotherapy.
LOCATION:Peterhouse Theatre
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