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SUMMARY:Motile behaviour and evolution of bacteria in antibiotic landscape
 s  - Nuno Miguel Oliveira\, DPhil\, BBSRC Discovery Fellow &amp\; Teaching
  Bye-Fellow in Zoology (Christ's College)
DTSTART:20221130T140000Z
DTEND:20221130T150000Z
UID:TALK184952@talks.cam.ac.uk
CONTACT:Samantha Noel
DESCRIPTION:Most of our knowledge about bacterial biology comes from well-
 mixed flasks but in natural and clinical settings bacteria often experienc
 e spatiotemporal gradients of multiple factors\, ranging from nutrients an
 d waste products to antimicrobials. By virtue of favouring the study of ho
 mogenous cultures\, we know little about how bacteria respond to spatially
  heterogenous environments and how such heterogeneity affects bacterial ad
 aptation. In this talk\, I will discuss how bacteria control their motilit
 y and evolve in antibiotic landscapes. In the first part of talk\, I will 
 show that biofilm bacteria actively move towards antibiotics when exposed 
 to spatial gradients of antibiotics in microfluidic experiments\, and I wi
 ll explain why they have such a perplexing motile behaviour. The devil is 
 in microbial ecology. In the second part of the talk\, I will use numerica
 l and analytical results to show that bacterial motility governs the evolu
 tion of antibiotic resistance. In particular\, I will clarify why cell mot
 ility can accelerate and decelerate the rate of bacteria adaptation in ant
 ibiotic landscapes. Again\, the devil is in microbial ecology. I will argu
 e that we need to appreciate microbial stress behaviour\, ecology and evol
 ution to improve how we respond to microbes and their impacts on us. 
LOCATION:CMS\, Meeting Room 15
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