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SUMMARY:Physical limits of cell migration - Katarina Wolf\, Department of 
 Cell Biology\, Nijmegen Centre for Molecular Life Sciences
DTSTART:20100121T130000Z
DTEND:20100121T140000Z
UID:TALK18667@talks.cam.ac.uk
CONTACT:Katrien Van Look
DESCRIPTION:Cancer cell invasion into interstitial tissue is a key step to
  cancer progression and metastasis.\nCell surface proteases facilitate pro
 teolytic invasion. Upon MMP inhibitor treatment\, cancer cells may switch 
 to nonproteolytic compensatory movement or stop to migrate\, yet the tissu
 e conditions that facilitate or prevent non-proteolytic migration remain u
 nknown. We here define the mechanisms and physical limits of protease-inde
 pendent migration\, using spatially controlled 3D fibrillar lattices of no
 n-crosslinked macroporous or cross-linked microporous collagen. In additio
 n\, pore size within the same collagen preparation was modified by density
  titration or assembly speed variation. Consistent with gap diameters\, ca
 ncer cells maintained after MMP inhibition amoeboid nuclear squeezing in m
 acroporous lattices\, whereas microporous networks forced migration arrest
 . Thus\, rather than the presence or absence of cross-links\, the physical
  dimensions of ECM gaps and pores control nuclear morphology\, and therefo
 re efficiency and protease requirements of cancer cell migration.\n
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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