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SUMMARY:Early onset depressions: Can neuroscience aid clinical decision ma
 king? - Professor Ian Goodyer\, Department of Psychiatry\, Institute of De
 velopmental Psychiatry
DTSTART:20090929T154500Z
DTEND:20090929T161500Z
UID:TALK18693@talks.cam.ac.uk
CONTACT:Hannah Critchlow
DESCRIPTION:This talk is part of the Cambridge Clinical Neuroscience and M
 ental Health Symposium\, 29th - 30th September 2009 at West Road Concert H
 all. This event is free to attend for cambridge neuroscientists although r
 egistration is required. To register\, and for further information\, pleas
 e visit: http://www.neuroscience.cam.ac.uk/cnmhs/\n\n*Abstract:* In a pros
 pective study of well adolescents at risk for clinical depression we deter
 mined if the known association between morning waking cortisol levels and 
 the subsequent onset of an episode of major depression was moderated by th
 e short (‘s’) allele in the promoter region of the serotonin transport
 er gene (5HTTLPR).  We showed that ‘s’ carriers (s/l and s/s) had a si
 gnificantly different  distribution of morning cortisol compared to  l/l c
 arriers. There was a significant gene x hormone interaction predicting epi
 sode onset [ ‘s’ x morning cortisol\, odds ratio = 10.2 (se 10.6) Z= 2
 .23\, p= 0.026\, 95% CI = 1.3-78.4]. The marginal predicted probability of
  being depressed for those with one or both copies of the short ‘s’ al
 lele begin to increase from the 50th centile (log level>=1.03ng/ml) of mor
 ning cortisol upwards. Above this level 21 (68%) of the 32 cases occur and
  of these 17 (81%) carry one or both ‘s’ alleles.\n\n*Biography:* Prof
 essor Ian Goodyer is professor of Child and Adolescent Psychiatry at the U
 niversity of Cambridge. He conducts research in the fields of emotional an
 d behavioural disorders in childhood and adolescence. He has focussed on p
 sychoendocrine and neurocognitive components of risk for mental illnesses 
 that emerge in the second decade of life.  His research group utilize gene
 tically and developmentally sensitive prospective and experimental designs
  and undertake randomized controlled trials in depression and conduct diso
 rders. He is particularly interested in determining the role of early expe
 rience on the cognitive control of emotions\, the effects of cortisol hype
 rsecretion on the developing brain\, the biological basis of resilience in
  the face of adversity and the effectiveness of psychological and pharmaco
 logical treatments on depression in the medium as well as the short term. 
 He has contributed to the UK National Institute of Excellence (NICE) guide
 lines for the treatment of child and adolescent depression. \n
LOCATION:West Road Concert Hall
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