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SUMMARY:Using single-molecule manipulation to probe the dynamics of protei
 n and DNA\nmolecules - Professor Ching-Hwa Kiang (Department of Physics &a
 mp\; Astronomy\, Rice University\, USA)
DTSTART:20090615T133000Z
DTEND:20090615T143000Z
UID:TALK18756@talks.cam.ac.uk
CONTACT:Dr Mark Miller
DESCRIPTION:Single-molecule manipulation of biological molecules opens a n
 ew door for a close-up investigation of the complexbiological interactions
 . Nanomanipulation tools such as atomic force microscope and optical tweez
 ers are used topull single molecules while monitoring their force response
 . Using the recently derived nonequilibrium work theorem\, i.e.\, Jarzynsk
 i's\nequality\, we were able to determine the equilibrium properties from 
 these nonequilibrium measurements results.  I will describe the free energ
 y reconstruction and velocity dependence of titin I27 stretching and unfol
 ding using Jarzynski's equality.  The results and implication of propertie
 s determined by mechanical manipulation of single-molecules will be discus
 sed.\nFinally\, I will present single-molecule studies of biological syste
 ms such as mechanical melting of DNA and protein folding\, and discuss the
  implications and challenges as well as the significance of single-molecul
 e manipulation in biological functions.
LOCATION:Unilever Lecture Theatre\, Department of Chemistry
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