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SUMMARY:Neurological Studies of Rewards Processing In Major Depression - D
 r Wayne C Drevets\, Senior Investigator and Chief of Sectioning on Mood an
 d Anxiety Disorders for the National Institute of Mental Health in the USA
DTSTART:20090928T173000Z
DTEND:20090928T183000Z
UID:TALK18800@talks.cam.ac.uk
CONTACT:Hannah Critchlow
DESCRIPTION:This lecture is free to attend although registration is requir
 ed. *To register\, and for more information\, please visit: http://www.neu
 roscience.cam.ac.uk/cnmhs/*\n\nAs a satellite to the Clinical Neuroscience
  and Mental Health Symposium\, Dr Wayne C Drevets\, Senior Investigator an
 d Chief of Sectioning on Mood and Anxiety Disorders for the National Insti
 tute of Mental Health in the USA\, will be delivering the 2009 Paykel Lect
 ure entitled "Neurological Studies of Rewards Processing In Major Depressi
 on" on the 28th September\, 6:30 pm in the The Martin Cohen Lecture Theatr
 e\, Cancer Research UK\, Cambridge Research Institute\, The Lee Ka Shing C
 entre Cambridge Biomedical Campus (Addenbrooke's Site) Robinson Way. \n\nC
 offee and biscuits will be available before the lecture\, from 6.00 pm wit
 h a reception after the lecture with wine and canapes and an opportunity f
 or you to meet Dr Drevets.\n\n*Talk Abstract*: A deficit in central reward
  processing is thought to underlie the diminished ability of individuals w
 ith major depressive disorder (MDD) to derive pleasure from activities onc
 e deemed enjoyable. Notably\, the corticolimbic networks shown to mediate 
 and modulate the neural processing of reward and behavioral incentive in s
 tudies of experimental animals also have been implicated in the pathophysi
 ology of MDD by data from neuroimaging and neuropathological studies. Thes
 e networks involve the orbitofrontal cortex (OFC)\, amygdala\, hippocampus
  and anatomically related areas of the striatum where reductions in grey m
 atter volume and alterations in neurophysiological activity exist in some 
 MDD subgroups. Using PET and fMRI imaging my colleagues and I investigated
  patterns of neural activity and dynamic neurotransmitter function within 
 these circuits in depressed subjects as they performed reward processing t
 asks. While performing a monetary incentive delay (MID) task\, depressed M
 DD subjects showed altered hemodynamic activity in the OFC\, hippocampus\,
  amygdala and accumbens\, as they anticipated initiating behavioral respon
 ses aimed at acquiring rewards or avoiding losses. These physiological abn
 ormalities were associated with impaired modulation of the behavioral resp
 onse to changing incentive levels. Currently remitted subjects with MDD sh
 owed an abnormal diathesis to develop both this same behavioral pattern on
  the MID task and abnormal glucose metabolism in the OFC and accumbens are
 a under catecholamine depletion. Converging with these data\, depressed pa
 tients also showed abnormally reduced dopamine release during reward proce
 ssing and reduced dopamine D1 receptor binding in the anteroventral striat
 um. The results of these studies will be integrated with relevant neurobio
 logical data from preclinical studies into circuitry-based models that may
  elucidate the neural basis of the anhedonia\, amotivation and mood-congru
 ent processing biases manifest clinically in MDD. \n\n*Biosketch:* Dr. Dre
 vets\, M.D. joined the Intramural Research Program of the National Institu
 te of Mental Health in 2001\, after serving on the Psychiatry Department f
 aculties of the University of Pittsburgh School of Medicine for four years
  and the Washington University School of Medicine for nine years.  Dr. Dre
 vets received his M.D. degree from the University of Kansas\, and complete
 d residency training in psychiatry and post doctoral fellowship training i
 n imaging sciences at Washington University. Dr. Drevets’ research focus
 es on applying positron emission tomography (PET) and magnetic resonance i
 maging (MRI) to characterize the pathophysiology of mood disorders. \n
LOCATION:The Martin Cohen Lecture Theatre\, Cancer Research UK\, Cambridge
  Research Institute\, The Lee Ka Shing Centre Cambridge Biomedical Campus 
 (Addenbrooke's Site) Robinson Way
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