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SUMMARY:Analysing the pharmacokinetics and pharmacodynamics of drugs in vi
 vo by upgrading in vitro data based on mathematical modelling - Wilhelm Hu
 isinga\, National University of Ireland\, Maynooth
DTSTART:20100201T160000Z
DTEND:20100201T170000Z
UID:TALK18848@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:Experimental limitations as well as practical and ethical\nasp
 ects set a barrier to our ability to analyse the pharmacokinetics and\npha
 rmacodynamics of drugs in vivo\, in particular in human. In this talk\,\nw
 e will show how a physiologically- &  mechanism-based modelling\napproach 
 in combination with in vitro data can be used to analyse\,\nunderstand and
  optimize drug pharmacokinetics and effect in vivo. We\nwill illustrate ho
 w  physiologically-based pharmacokinetic (PBPK) models\ncan be used to pre
 dict drug pharmacokinetics prior to any in vivo\nexperiment\, how PBPK mod
 els\, potentially evaluated and refined through\nfirst in vivo experiments
 \, can then be reduced to simple compartment\nmodels representing essentia
 l PK characteristics of a drug\, and how\nsingle cell experiments\, integr
 ated into such compartment models\, offer\nthe potential to elucidate and 
 optimize drug action\, in particular for\ntherapeutic protein drugs.
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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