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SUMMARY:BSU Seminar: &quot\;Making all pairwise comparisons in multi-arm c
 linical trials without control treatment&quot\; - Dr Thomas Burnett\, Univ
 ersity of Bath
DTSTART:20221101T140000Z
DTEND:20221101T150000Z
UID:TALK191408@talks.cam.ac.uk
CONTACT:Alison Quenault
DESCRIPTION:The standard paradigm for confirmatory clinical trials is to c
 ompare experimental treatments with a control\, for example the standard o
 f care or a placebo. However\, it is not always the case that a suitable c
 ontrol exists. Efficient statistical methodology is well studied in the se
 tting of randomised controlled trials. This is not the case if one wishes 
 to compare several experimental with no control arm. We propose hypothesis
  testing methods suitable for use in such a setting.  These methods are ef
 ficient\, ensuring the error rate is controlled at exactly the desired rat
 e with no conservatism. This in turn yields an improvement in power when c
 ompared with standard methods one might otherwise consider using\, such as
  a Bonferroni adjustment. The proposed testing procedure is also highly fl
 exible. We show how it may be extended for use in multi-stage adaptive tri
 als\, covering the majority of scenarios in which one might consider the u
 se of such procedures in the clinical trials setting. With such a highly f
 lexible nature\, these methods may also be applied more broadly outside of
  a clinical trials setting.
LOCATION:Large Seminar Room\, East Forvie Building\, Forvie Site\, Robinso
 n Way\, Cambridge CB2 0SR
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