BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Integrative models of heart function in health and disease - Traya
 nova\, N (Johns Hopkins)
DTSTART:20090722T081500Z
DTEND:20090722T090000Z
UID:TALK19142@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Simulating cardiac electromechanical function is one of the mo
 st striking examples of a successful integrative multi-scale modeling appr
 oach applied to a living system directly relevant to human disease. Today\
 , thanks to nearly fifty years of research in the field and the rapid prog
 ress of high-performance computing\, we stand at the threshold of a new er
 a: anatomically-detailed tomographically-reconstructed models that integra
 te from the ion channel or sarcomere to the electromechanical interactions
  in the intact heart are being developed. Such models\, while still in its
  infancy\, hold high promise for interpretation of clinical and physiologi
 cal measurements in terms of cellular mechanisms\; for improving the basic
  understanding of the mechanisms of dysfunction in disease conditions\, su
 ch as reentrant arrhythmias\, myocardial ischemia\, and heart failure\; an
 d for the development and performance optimization of medical devices\, ul
 timately enabling manufacturers to predict device and procedure performanc
 e and outcome prior to clinical trials. Attempt is made to extend these mo
 dels beyond electromechanics and include regulatory processes such as ener
 gy metabolism and signal transduction. Here we provides specific examples 
 of the state-of-the-art in cardiac integrative modeling\, including 1) unc
 overing the role of ventricular structure in defibrillation\; 2) improving
  ventricular ablation procedure by using MRI reconstructed heart geometry 
 and structure to investigate the reentrant circuits formed in the presence
  of an infarct scar\; 3) employing an electromechanical model of the heart
  to determine the electromechanical delay in the heart\; and 4) understand
 ing the origin of mechanically-induced ventricular premature beats in acut
 e regional ischemia. 
LOCATION:Seminar Room 1\, Newton Institute
END:VEVENT
END:VCALENDAR