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SUMMARY:Personalised electromechanical model of the heart for the predicti
 on of the acute effects of cardiac resynchronisation therapy - Sermesant\,
  M (King's College London)
DTSTART:20090723T144500Z
DTEND:20090723T150000Z
UID:TALK19162@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Cardiac resynchronisation therapy (CRT) has been shown to be a
 n effective adjunctive treatment for patients with dyssynchronous ventricu
 lar contraction and symptoms of the heart failure. However\, clinical tria
 ls have also demonstrated that up to 30% of patients may be classified as 
 non-responders. In this article\, we present how the personalisation of an
  electromechanical model of the myocardium could help the therapy planning
  for CRT. We describe the four main components of our myocardial model\, n
 amely the anatomy\, the electrophysiology\, the kinematics and the mechani
 cs. For each of these components we combine prior knowledge and observable
  parameters in order to personalise these models to patient data. Then the
  acute effects of a pacemaker on the cardiac function are predicted with t
 he in silico model on a clinical case. This is a proof of concept of the p
 otential of virtual physiological models to better select and plan the the
 rapy.
LOCATION:Seminar Room 1\, Newton Institute
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