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SUMMARY:Mapping DNA replication stress in parasites and cancer cells with 
 long-read sequencing and AI   - Dr. Michael A. Boemo\, Research Group Lead
 er\, Department of Pathology
DTSTART:20230215T140000Z
DTEND:20230215T150000Z
UID:TALK192044@talks.cam.ac.uk
CONTACT:Samantha Noel
DESCRIPTION:Every time a cell divides\, it must copy (or “replicate”) 
 its genome exactly once\, which it achieves through the parallel action of
  thousands of replication forks. One of the most serious errors in DNA rep
 lication occurs when replication forks stall\, which happens when the fork
  encounters an obstacle that it cannot pass. The frequent slowing or stall
 ing of replication forks\, termed “replication stress”\, is rare in he
 althy human cells but common in both cancer cells and parasites. Replicati
 on stress is therefore a common therapeutic target for anti-malarial and c
 ancer chemotherapies\, but we have a relatively poor understanding of wher
 e\, when\, why\, and how often replication forks stall under these therapi
 es. I will discuss our recent progress towards answering these questions\,
  whereby we are using long-read nanopore DNA sequencing together with AI t
 o measure the movement and stress of thousands of replication forks across
  the genomes of human cancer cells and the malaria parasite Plasmodium fal
 ciparum.
LOCATION:CMS\, Meeting Room 15
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