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SUMMARY:New Frontiers in PKA Signaling - Susan Taylor\, Professor of Chemi
 stry and Biochemistry and a Professor of Pharmacology at the University of
  California\, San Diego
DTSTART:20221109T113000Z
DTEND:20221109T123000Z
UID:TALK192440@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Over thirty years have passed since that first PKA structure w
 as solved and in so many ways PKA has served as the poster child for the p
 rotein kinase superfamily. In addition to trapping each step of catalysis 
 in a crystal lattice and solving isoform-specific holoenzyme structures\, 
 by comparing PKA to other kinases we discovered the Regulatory and Catalyt
 ic Spines. This hydrophobic core architecture provides us with a conceptua
 l framework to better understand how all protein kinases are activated and
  regulated as molecular switches. Over the past three years\, however\, we
  have also made unanticipated discoveries that open some new frontiers in 
 PKA signaling. C isoforms\, for example\, are virtually unexplored alth
 ough they account for ~50% of PKA signaling in neurons. The biomolecular c
 ondensates formed by RI that serve as a “Sponge” for compartmentali
 zing cAMP is another new concept as is our discovery of a PKI-like sequenc
 e embedded in the tail of Smoothened\, the GPCR that regulates Sonic hedge
 hog signaling. Our approach to build an interdisciplinary platform where w
 e can move seamlessly from atomic level resolution to cells and tissues al
 lows us to quickly build on new discoveries
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m\, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99725572898?pwd=NG82MzVpQmcz
 czAvdkZzN2lJNkt1UT09
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