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SUMMARY:Brain charts for the human lifespan. - Dr Richard Bethlehem (Depar
 tment of Psychology\, Cambridge)
DTSTART:20221125T163000Z
DTEND:20221125T180000Z
UID:TALK192443@talks.cam.ac.uk
CONTACT:John Mollon
DESCRIPTION:Over the past few decades\, neuroimaging has become a ubiquito
 us tool in basic research and clinical studies of the human brain. However
 \, no reference standards currently exist to quantify individual differenc
 es in neuroimaging metrics over time\, in contrast to growth charts for an
 thropometric traits such as height and weight. Here we present an interact
 ive open resource to benchmark brain morphology derived from any current o
 r future sample of MRI data (http://www.brainchart.io/). With the goal of 
 basing these reference charts on the largest and most inclusive dataset av
 ailable\, acknowledging limitations due to known biases of MRI studies rel
 ative to the diversity of the global population\, we aggregated 123\,984 M
 RI scans\, across more than 100 primary studies\, from 101\,457 human part
 icipants between 115 days post-conception to 100 years of age. MRI metrics
  were quantified by centile scores\, relative to non-linear trajectories o
 f brain structural changes\, and rates of change\, over the lifespan. Brai
 n charts identified previously unreported neurodevelopmental milestones\, 
 showed high stability of individuals across longitudinal assessments\, and
  demonstrated robustness to technical and methodological differences betwe
 en primary studies. Centile scores showed increased heritability compared 
 with non-centiled MRI phenotypes\, and provided a standardized measure of 
 atypical brain structure that revealed patterns of neuroanatomical variati
 on across neurodevelopmental\, neurological and psychiatric disorders. In 
 summary\, brain charts are an essential step towards robust quantification
  of individual variation benchmarked to normative trajectories in multiple
 \, commonly used neuroimaging phenotypes.
LOCATION:Ground Floor Lecture Theatre\, Department of  Psychology
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