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SUMMARY:LMB Seminar: Mechanism and regulation P element transposition in D
 rosophila  - Donald Rio\, Professor of Biochemistry\, Biophysics and Struc
 tural Biology\, Dept. of Molecular and Cell Biology\, University of Califo
 rnia\, Berkeley\, USA
DTSTART:20221129T160000Z
DTEND:20221129T170000Z
UID:TALK192611@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Transposable elements are ubiquitous in the genomes of all kno
 wn organisms from bacteria to humans.  These mobile genetic elements are k
 nown to contribute to genome evolution and organization.  P elements were 
 discovered in the fruit fly\, Drosophila melanogaster\, because they cause
  a genetic syndrome called hybrid dysgenesis where their uncontrolled mobi
 lity leads to sterility\, mutations and chromosomal rearrangements.  P ele
 ments are mobilized using a cut-and-paste mechanism by a DNA binding trans
 posase enzyme that uses GTP as a cofactor at multiple stages of the reacti
 on pathway.  The interaction of P elements with their host has led to mult
 iple regulatory strategies to regulate and restrict P element mobility to 
 the germline involving alternative pre-mRNA splicing and the small piwi-in
 teracting RNA (piRNA) pathway.  Genome sequencing has identified P element
  transposase-related genes\, called THAP9\, found in vertebrate genomes.  
 I will discuss mechanistic studies of P element transposition and how tran
 sposition is regulated
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m\, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94108711681?pwd=cXN4VGlQVHBZ
 YkpMUVJ0SXV3emtaUT09
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