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SUMMARY:Epigenetic memoirs of a parasite - Dr Richard Bartfai (Radboud Uni
 versiteit\, The Netherlands) 
DTSTART:20230301T160000Z
DTEND:20230301T170000Z
UID:TALK192701@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:Plasmodium falciparum is a unicellular eukaryotic pathogen tha
 t is responsible for half a million death yearly. The incredible capacity 
 of the parasites to adapt to vastly different environments in the human ho
 st and mosquito vector as well as to survive changes in the environment pr
 ovides a foundation for the parasite’s evolutionary success. We and othe
 rs have shown that this adaptive capacity to a large extent is enabled by 
 epigenetic regulatory mechanisms and in particular H3K9me and heterochroma
 tin protein 1 mediated gene silencing. In this lecture\, I will provide an
  overview of our current understanding of how plasticity of the parasite
 ’s epigenome contributes to parasite development and pathogenicity. I wi
 ll then focus on a peculiar group of epigenetically-regulated RNA-binding 
 proteins that signifies liver stage dormancy of malaria parasites.\n\nWe e
 ncourage in person attendance but the talk will also be streamed via "zoom
 ":https://zoom.us/j/93777349694?pwd=TUVkZkQ3YXU3NmN4YkZELzJWZXNEQT09\n\nOr
 \, go to "https://zoom.us/join":https://zoom.us/join and enter meeting ID:
  937 7734 9694 and password: 6QuJjAx1jM
LOCATION:Seminar Room\, Tennis Court Road\, Dept of Pathology.
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