BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:Metabolic control of myeloid cell function in chronic central ner vous system inflammation - Dr. Luca Peruzzotti-Jametti - Clinical Neurosci ences DTSTART:20221205T180000Z DTEND:20221205T190000Z UID:TALK192734@talks.cam.ac.uk CONTACT:Brandon Spencer Lockey DESCRIPTION:Many people living with multiple sclerosis (MS) experience asp ects of normal aging years\, or even decades\, ahead of schedule. As their disease progresses\, people with MS show reduced mobility and impaired co gnitive functions\, which all lead to a significant reduction of their act ivities of daily living.\nSustained activation of resident and infiltratin g myeloid cells is a common hallmark of several chronic neurological disea ses\, including MS. In MS\, chronic active\, slowly expanding\, smoldering lesions are characterized by the accumulation of myeloid cells at the les ion edge and are associated with brain volume loss and progressive disabil ity. Extensive metabolic rewiring occurs in cells in response to the local microenvironment as cells deal with shifting availability of energetic su bstrates and signalling molecules that ultimately modify their effector fu nctions. However\, the role of myeloid cell metabolism in driving persiste nt central nervous system inflammation in MS and other neurodegenerative d iseases has not been fully elucidated yet.\nUsing a complementary multiomi cs approaches\, we identified a new molecular signature that sustains the persistent activation of microglia dependent on altered mitochondrial comp lexes activity driving the production of reactive oxygen species. We showe d that specific TCA cycle metabolites (e.g.\, succinate) and lipid species accumulate in chronic central nervous system inflammation and modulate my eloid function\, as well as key neuroimmune interactions. Finally\, we sho wed that it is possible to correct the mitochondrial dysfunction of myeloi d cells by using small molecules and acellular approaches\, including mito chondria delivery via extracellular vesicles.\nOur work is shedding new li ght on the role of mitochondrial metabolism in guiding complex cellular fu nctions in chronic central nervous system inflammation.\n\nDr. Luca Peruzz otti-Jametti is a Senior Research Associate (Wellcome Trust CRCD Fellow) a nd Honorary Neurology Consultant at the Department of Clinical Neuroscienc es.\n\nJoin Zoom Meeting\nhttps://us02web.zoom.us/meeting/register/tZwtfuq oqj8iH9V1mY4lgwsTfG7VyOP1N1nB\n LOCATION:Hybrid &\; Department of Chemistry (Pfizer lecture theatre) END:VEVENT END:VCALENDAR