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SUMMARY:Uncovering the role of regulatory T cells in tissue regeneration -
  Dr Ye Zheng\; Salk Institute for Biological Studies
DTSTART:20230119T140000Z
DTEND:20230119T150000Z
UID:TALK193091@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:The maintenance of tissue homeostasis in steady state or under
  stress is dependent on the proper communication between the stem cells an
 d the supporting cells in their microenvironment or “niche”. In additi
 on to promoting immune tolerance\, regulatory T cells (Tregs) have recentl
 y emerged as a critical component of the stem cell niche in the hair folli
 cle (HF)\, injured muscle\, bone marrow\, and small intestine to support s
 tem cell differentiation or maintain their quiescence. How Treg cells sens
 e the dynamic signals in the niche environment and communicate with stem c
 ells during tissue regeneration is largely unknown. Here\, by using HF as 
 a model\, we uncover a hitherto unrecognized function of steroid hormone g
 lucocorticoid that instructs skin-resident Treg cells through glucocortico
 id receptor (GR) to facilitate hair follicle stem cell (HFSC) activation a
 nd HF regeneration. Ablation of GR signaling in Tregs blocked depilation-i
 nduced hair regeneration and natural hair growth without affecting Treg’
 s immune suppressive function. Mechanistic study revealed that GR signalin
 g induces skin-resident Tregs to produce TGF-b3\, which directly activates
  Smad2/3 in HFSCs and facilitates HFSC activation and proliferation. Our s
 tudy identifies a novel crosstalk between skin-resident Tregs and HFSCs me
 diated by the GR/TGF-b3 axis\, highlighting a new avenue to manipulate Tre
 gs to support tissue regeneration.\n \nDr. Ye Zheng is an associate profes
 sor in the NOMIS Center for Immunobiology and Microbial Pathogenesis at th
 e Salk Institute for Biological Studies. He was the first to map the Foxp3
  cistrome in Tregs\, which served as a blueprint for subsequent studies on
  molecular mechanisms of Treg function. His lab is currently investigating
  in three areas of Treg biology. First\, they are dissecting the molecular
  pathways that regulate Treg cell homeostasis and function\, which has imp
 ortant implications in treating autoimmune diseases and cancer immunothera
 py. Second\, they are exploring how T cell differentiation and function ar
 e regulated by metabolic regulators such as nuclear hormone receptors in t
 he context of autoimmune diseases and metabolic diseases. Third\, they are
  investigating Treg cell’s non-canonical role in crosstalk with stem cel
 ls and promoting tissue repair and regeneration.\n\n\nClick here to join l
 ive - https://us06web.zoom.us/j/89980735662
LOCATION:Online via zoom
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