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SUMMARY:The Value of Metabolomic Biomarkers in UK Biobank – Molecular In
 sights and Health Screening Opportunities - Peter Würtz (Nightingale Heal
 th Ltd. and University of Helsinki)
DTSTART:20221209T130000Z
DTEND:20221209T140000Z
UID:TALK193597@talks.cam.ac.uk
CONTACT:Spencer Keene
DESCRIPTION:"Blood metabolites and lipids are predictors for future diseas
 e onset. We will show how biomarker profiling by Nightingale NMR in UK Bio
 bank provides novel scientific insights on connections between different d
 iseases and opens possibilities to predict the risk of many disease outcom
 es simultaneously.\n\nNightingale Health Plc has developed an NMR-based me
 tabolomics assay\, which quantifies lipoprotein lipids\, fatty acids and s
 mall molecules such as amino acids\, glycolysis metabolites and inflammati
 on markers. These NMR biomarker profiles have recently been measured in 30
 0\,000 participants from UK Biobank. The initial results reveal a prominen
 t role of abundant circulating lipids and metabolites as risk markers beyo
 nd cardiometabolic diseases\, including susceptibility to infectious disea
 ses and risk for the onset of respiratory diseases\, joint disorders and m
 ental health outcomes.\n\nThe talk will also highlight the application of 
 the biomarkers for risk prediction of various common diseases to identify 
 individuals at several fold increased risk compared to the remaining popul
 ation. The prediction results complement information from polygenic risk s
 cores. The results highlight how metabolomic profiling in large biobanks c
 an accelerate translation and may find use for risk prediction of multiple
  common diseases. "
LOCATION:Heart and Lung Research Institute (ground floor)
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