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SUMMARY:Connectome needs electrophysiology to determine function – compu
 ter simulations can help\, too - Cengiz Gunay
DTSTART:20221208T100000Z
DTEND:20221208T110000Z
UID:TALK193609@talks.cam.ac.uk
CONTACT:Daniel Han
DESCRIPTION:Recent advancements in high-throughput analysis of brain conne
 ctivity have been revealing. However\, without knowledge of neuronal dynam
 ics\, the connectome alone provides limited understanding of nervous syste
 m functionality and disorders. In particular\, dysfunction of neuronal ion
  channels can cause major central nervous system disorders such as epileps
 y that affects about 1% of the global population. Role of ion channels in 
 electroshock-induced seizures can be investigated using the bang-sensitive
  family of mutant fruit flies. However\, developmental compensation in mut
 ants prevents relating channel activity to behavioral outcomes. Channel ef
 fects were successfully measured in isolation previously using a computati
 onal neuron model. This model only represented a single motoneuron without
  considering contributions from other neurons. The recent availability of 
 electron micrograph connectivity from the fly larva allows reconstructing 
 a more detailed anatomical morphology of this motoneuron\, which includes 
 the surrounding circuit. We propose to reconstruct this circuit on the com
 puter to investigate effects of synaptic inputs on seizure activity via si
 mulation.
LOCATION:Klug Seminar Room\, Level 2 2A180\, MRC LMB
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